{"search_session":{},"preferences":{"l":"zh","queryLanguage":"zh"},"patentId":"147-117-473-486-646","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"147-117-473-486-646"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10709,"type":"PATENT","title":"Rockefeller University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":4213,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8226,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Rockefeller University\"; \"Univ* Rockefeller\"; \"Univ* Rockef*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4020
Search Applicants and Owners separately: \"Rockefeller University\"; \"Univ* Rockefeller\"; \"Univ* Rockef*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 4020
(a) contacting an agent with phosphatase 2C (“PP2C”) and Ser137-phosphorylated Dopamine- and cyclic-AMP-Regulated PhosphoProtein of molecular weight 32,000 Dalton (“DARPP-32”);\n
(b) detecting the amount of dephosphorylation of Ser137-phosphorylated DARPP-32; and\n
(c) testing the agent in an animal model of depression,\nwherein the agent is identified as an agent for use in treating depression if a decrease in the dephosphorylation of Ser137-phosphorylated DARPP-32 is detected in the presence of the agent in step (b) and if the agent is effective in the animal model tested in step (c)."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the animal model is a rodent learned helplessness model."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the rodent learned helplessness animal model is a tail suspension test, and wherein a reduction in immobility indicates that the agent is useful for treatment of depression."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 2, wherein the rodent learned helplessness animal model is a forced swim test, and wherein an increase in swimming indicates that the agent is useful for treatment of depression."],"number":4,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}