Regulation Of Cell Growth By Muc1


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The invention features a method of identifying a compound that inhibits (a) the physical interaction (binding) between MUC1 and tumor progressors (e.g., ²-catenin, c-Src, EGF-R, p120 ctn , or PKC´) and/or (b) phosphorylation of MUC1 by tumor progressors with kinase activity (e.g., c-Src, EGF-R, or PKC´). The invention also includes a method of inhibiting an interaction between MUC1 and ²-catenin and a method of inhibiting expression of MUC1 or a tumor progressor in a cell.


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Document History
  • Publication: Aug 20, 2008
  • Application: Dec 26, 2001
    EP EP 08005820 A
  • Priority: Dec 26, 2001
    EP EP 01994391 A
  • Priority: Jul 27, 2001
    US US 30830701 P
  • Priority: Dec 22, 2000
    US US 25759000 P

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