Pluripotency Determining Factors And Uses Thereof

Abstract

Pluripotency determining factors are described which act intracellularly and maintain a pluripotent cell in a pluripotent state in the absence of gp130 activation, which maintain or confer pluripotency of a human stem cell, which maintain or confer pluripotency of a mouse ES cell, and which maintain or confer pluripotency of a stem cell from a non-permissive strain of mice. The factors and vectors encoding or activating the factors are used to maintain and derive pluripotent cells, especially of higher mammals, including humans.


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Document History
  • Publication: Mar 30, 2010
  • Application: Apr 21, 2005
    US US 50297205 A
  • Priority: Jan 30, 2003
    GB GB 0300366 W
  • Priority: Jan 30, 2002
    GB GB 0202149 A

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