{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"146-179-831-692-069","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"146-179-831-692-069","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8909,"type":"PATENT","title":"Cornell Univ Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":11969,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8223,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
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Total patent: 10677
Search applicants and owners= \"Cornell Univ\", \" Univ Cornell\", \" Cornell Res* Found*\", \"Corne* Univ* Tech* Enter* Comm*\".
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Total patent: 10677
providing a population of neural progenitor cells and\n
immortalizing the population of neural progenitor cells by introduction of a nucleic acid sequence encoding telomerase reverse transcriptase operably linked to a promoter, either before or after the neural progenitor cells are enriched or purified wherein said telomerase reverse transcriptase is produced in sufficient quantity to immortalize said neural progenitor cells."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the immortalized neural progenitor cells give rise to lineage-restricted neural progenitor cells and their progeny."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said immortalizing is carried out by transducing the enriched or purified population of neural progenitor cells."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the enriched or purified population of neural progenitor cells are transduced by viral-mediated transduction."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein said viral-mediated transduction is selected from the group consisting of adenovirus-mediated transduction, retrovirus-mediated transduction, adeno-associated virus-mediated transduction, lentivirus-mediated transduction, and herpesvirus-mediated transduction."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein said viral-mediated transduction is retrovirus-mediated transduction."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein said viral-mediated transduction is adenovirus-mediated transduction."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein said viral-mediated transduction is adeno-associated virus-mediated transduction."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein said viral-mediated transduction is lentivirus-mediated transduction."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 5, wherein said viral-mediated transduction is herpesvirus-mediated transduction."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the enriched or purified population of neural progenitor cells are transduced by electroporation."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the enriched or purified population of neural progenitor cells are transduced by biolistic transduction."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 3, wherein the enriched or purified population of neural progenitor cells are transduced by liposomal-mediated transduction."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said immortalizing is carried out by transducing the enriched or purified population of neural progenitor cells with a vector encoding a telomerase reverse transcriptase."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 14, wherein the enriched or purified population of neural progenitor cells is lineage-restricted."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are selected from the group consisting of neuronal progenitor cells, oligodendrocyte progenitor cells, hippocampal progenitor cells, and neural stem cells."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are selected from dopaminergic progenitor cells, chlolinergic progenitor cells, motor neuronal progenitor cells, dorsal neuronal progenitor cells, ventrally-derived neuronal progenitor cells, ventral motor neuronal progenitor cells, ventral mesencephalic neuronal progenitor cells, and mesencephalic dopaminergic progenitor cells."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are from the spinal cord."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are from the brain."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the neural progenitor cells are from the forebrain, hypothalamus, midbrain, pons, or medulla."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are from the pancreatic islet."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are from the retina."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the neural progenitor cells are from a human."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 23, wherein the neural progenitor cells are from an adult."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 23, wherein the neural progenitor cells are of fetal origin."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said providing an enriched or purified population of neural progenitor cells comprises:\n
providing a mixed population of cell types which population includes neural progenitor cells;\n
selecting a promoter which functions in said neural progenitor cells;\n
introducing a nucleic acid molecule encoding a marker protein under control of said promoter into the mixed population of progenitor cells;\n
allowing the population of progenitor cells to express the marker protein; and\n
separating the cells expressing the marker protein from the mixed population of cells, wherein said separated cells are neural progenitor cells."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein the marker protein is a fluorescent protein."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein the promoter is selected from the group consisting of a MAP-1B promoter, an NCAM promoter, an HES-5HLH protein promoter, an α1-tubulin promoter, an α-internexin promoter, a GAP-43 promoter, a JC virus minimal core promoter, a cyclic nucleotide phosphorylase II promoter, a nestin enhancer, and musashi promoter."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 26, wherein the promoter is selected from the group consisting of a tyrosine hydroxylase promoter, a choline acetyltransferase promoter, a glutamic acid decarboxylase promoter, an MNR2 gene promoter, an Hb9 gene promoter, a sox2 homeodomain gene promoter, a bHLH protein promoter, a neurogenin-2 promoter, a NKx2.2 promoter, and an olig2 promoter."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 1, wherein said providing an enriched or purified population of neural progenitor cells comprises:\n
providing a mixed population of cell types which population includes neural progenitor cells and\n
separating the enriched or purified population of neural progenitor cells from the mixed population using surface marker protein specific to and naturally present in the enriched or purified population of neural progenitor cells."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 30, wherein the surface marker protein is selected from the group consisting of A2B5 and A133."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 1, wherein said immortalizing is carried out before the neural progenitor cells are enriched or purified."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["The method according to claim 1, wherein said immortalizing is carried out after the neural progenitor cells are enriched or purified."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["An enriched or purified population of immortalized neural progenitor cells comprising a nucleic acid sequence encoding telomerase reverse transcriptase operably linked to a heterologous promoter, wherein said telomerase reverse transcriptase is produced in sufficient quantity to immortalize said neural progenitor cells."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 34, wherein the progenitor cells are neural progenitor cells."],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 35, wherein the neural progenitor cells are selected from the group consisting of neuronal progenitor cells, oligodendrocyte progenitor cells, hippocampal progenitor cells, and neural stem cells."],"number":36,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 35, wherein the neural progenitor cells are from the spinal cord."],"number":37,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 35, wherein the neural progenitor cells are from the brain."],"number":38,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 38, wherein the neural progenitor cells are from forebrain, hypothalamus, midbrain, pons, or medulla."],"number":39,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 35, wherein the neural progenitor cells are from the pancreatic islet."],"number":40,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 35, wherein the neural progenitor cells are from the retina."],"number":41,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 35, wherein the neural progenitor cells are from a human."],"number":42,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 42, wherein the neural progenitor cells are from an adult."],"number":43,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 42, wherein the neural progenitor cells are of fetal origin."],"number":44,"annotation":false,"claim":true,"title":false},{"lines":["The enriched or purified population of claim 34, wherein the neural progenitor cells lack significant endogenous telomerase activity."],"number":45,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}