Determination Of Progress Of Chromosomal Aberrations In An Organism

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Abstract

Progress of chromosomal aberrations in an organism is determined using biological samples including nucleic acid molecules originating from normal cells and potentially from cells associated with a disease, at least some of the nucleic acid molecules being cell-free. Non-overlapping chromosomal regions of a reference genome of the organism are determined. At a plurality of times: for each of plural nucleic acid molecules, a location thereof in the reference genome is determined; and for each chromosomal region: a respective group of nucleic acid molecules is identified as being therefrom based on the identified locations; a respective value defining a property of the nucleic acid molecules is calculated and compared to a reference value to determine a classification of whether the chromosomal region exhibits a deletion or an amplification. The classifications at the plurality of times are used to determine the progress of the chromosomal aberrations in the organism.


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Document History
  • Publication: Nov 15, 2017
  • Application: Nov 30, 2011
    EP EP 17168020 A
  • Priority: Nov 30, 2011
    EP EP 11845367 A
  • Priority: Aug 31, 2011
    US US 201161529877 P
  • Priority: Nov 30, 2010
    US US 41839110 P

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