Interaction Between Cyclin D1 And Steroid Receptor Co-activators And Uses Thereof In Assays

Abstract

The present invention relates to the finding that cyclin D1 interacts in a ligand-independent fashion with coactivators of the SRC-1 family. The direct interaction of cyclin D1 enhances estrogen receptor (ER) mediated transcription and provides a novel target for the development of assays for substances which modulate the cell cycle. The invention provides assay methods for the prevention of growth of tumors, for assays for compounds useful in the prevention of tumors and compounds obtainable by such assays.


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Document History
  • Publication: Mar 14, 2006
  • Application: Sep 14, 2001
    US US 95303101 A
  • Priority: Sep 14, 2001
    US US 95303101 A
  • Priority: Apr 30, 1999
    US US 30230599 A
  • Priority: Feb 12, 1999
    GB GB 9900440 W
  • Priority: Aug 20, 1998
    GB GB 9818243 A
  • Priority: Feb 12, 1998
    GB GB 9803035 A

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