Benzopyran And Benzoxepin Pi3k Inhibitor Compounds And Methods Of Use

  • Published: Oct 1, 2009
  • Earliest Priority: Mar 31 2008
  • Family: 36
  • Cited Works: 0
  • Cited by: 56
  • Cites: 14
  • Additional Info: Full text
Abstract

Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.


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