Multi-day Delivery Of Biologically Active Substances


Compositions and methods for modifying biologically active substances to achieve multi-day delivery of such substances, particularly through oral or parenteral administration, are disclosed. The compositions include the biologically active substance conjugated to a carrier having a suitably long half life, typically more than one day, wherein the conjugate optionally contains a spacer linking the carrier to the biologically active substance. Pharmaceutical formulations of the conjugates are also disclosed, as are methods of extending delivery of a single dose of a biologically active substance for more than one day.

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Document History
  • Publication: Mar 31, 2015
  • Application: Jun 26, 2008
    US US 66597708 A
  • Priority: Jun 26, 2008
    US US 66597708 A
  • Priority: Jun 26, 2008
    US US 2008/0007983 W
  • Priority: Jul 12, 2007
    US US 95929807 P
  • Priority: Jul 9, 2007
    US US 95891407 P
  • Priority: Jun 27, 2007
    US US 93760407 P

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