Indolizineacetic Acids And Their Therapeutic Use As Ligands Of The Crth2 Receptor

  • Published: Jul 3, 2008
  • Earliest Priority: Dec 22 2006
  • Family: 6
  • Cited Works: 2
  • Cited by: 8
  • Cites: 0
  • Additional Info: Cited Works Full text
Abstract

Compounds of formula (I) are CRTH2 ligands, useful in the treatment of, inter alia, respiratory diseases: wherein R<SUP>1</SUP> is fluoro, chloro, cyano or trifluoromethyl; R<SUP>2</SUP> is hydrogen, fluoro or chloro; R<SUP>3</SUP> is hydrogen, fluoro, chloro or trifluoromethyl; X is -CH<SUB>2</SUB>-, -S-, -S(=O)- or -S(=O)<SUB>2</SUB>-; one of Y and Y<SUP>1</SUP> is hydrogen and the other is -C(=O)R<SUP>4</SUP>, or -S(=O)<SUB>2</SUB>R<SUP>4</SUP>, or -CR<SUP>5</SUP>R<SUP>6</SUP>OR<SUP>7</SUP> or a heterocyclic group selected from furanyl, thienyl, pyrrolyl, oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, 1,2,3-oxadiazolyl, 1,2,4-oxadiazolyl, 1,3,4-oxadiazolyl, 1,2,5-oxadiazolyl, furazanyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,3- thiadiazolyl, 1,2,5-thiadiazolyl, 1,3,4-thiadiazolyl, 1,2,4-thiadiazolyl, tetrazolyl, pyridinyl, pyridazinyl, pyrimidinyl, pyrazinyl, 1,2,4-triazinyl and 1,3,5-triazinyl any of which may be optionally substituted; R<SUP>4</SUP> is an optionally substituted cyclic amino group having 5, 6 or 7 ring atoms which is linked to the carbonyl or sulfonyl through a ring nitrogen; R<SUP>5</SUP> and R<SUP>6</SUP> are independently hydrogen, (C<SUB>1</SUB>C<SUB>3</SUB>)alkyl, cyclopropyl, or R<SUP>5</SUP> and R<SUP>6</SUP> taken together with the carbon atom to which they are attached form a 3-6 membered cycloalkyl ring; and R<SUP>7</SUP> is optionally substituted (C<SUB>1</SUB>-C<SUB>6</SUB>)alkyl or (C<SUB>3</SUB>- C<SUB>6</SUB>)cycloalkyl,


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Document History
  • Publication: Jul 3, 2008
  • Application: Dec 13, 2007
    WO GB 2007004789 W
  • Priority: Dec 22, 2006
    GB GB 0625842 A

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