Clock Gene And Methods Of Use Thereof

Abstract

The present invention discloses the identity of the first enzyme that has been demonstrated to be involved in maintaining circadian rhythms. This enzyme, the Drosophila DOUBLETIME protein is also shown to be an ortholog of human casein kinase-1epsi. In addition, a variant of this enzyme is shown to be cause of the hamster tau mutant phenotype. Thus the present invention also relates to variants of DOUBLETIME, and their nucleic acid and amino acid sequences. The present invention further provides methods of using these variants in drug assays and diagnostics.


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Document History
  • Publication: Nov 5, 2002
  • Application: Apr 20, 2000
    US US 55386700 A
  • Priority: Apr 20, 2000
    US US 55386700 A
  • Priority: Jun 18, 1999
    US US 33598399 A
  • Priority: Jun 19, 1998
    US US 9006898 P

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