Substances And Compositions For Enhancing Dna Repair And Methods Of Use

Abstract

The invention provides methods of preventing or treating a condition associated with DNA damage in an animal comprising the administration of a substance that interferes with the activity of the CUL4A ubiquitin ligase. The invention also provides a substance that interferes with the activity of CUL4A, as well as compositions comprising the interfering substance and a carrier. The substance of the invention preferably enhances nucleotide excision repair activity in an animal. The invention further provides methods of identifying substances that negatively or positively modulate the expression and/or activity of CUL4A.


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Owners (US)
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Document History
  • Publication: Aug 20, 2013
  • Application: Apr 29, 2009
    US US 99037309 A
  • Priority: Apr 29, 2009
    US US 99037309 A
  • Priority: Apr 29, 2009
    US US 2009/0042108 W
  • Priority: Apr 29, 2008
    US US 4886808 P

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