{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"134-240-959-780-353","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"134-240-959-780-353"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11916,"type":"PATENT","title":"Georgetown University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":3191,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8504,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
Search Applicants and Owners separately:Georgetown Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 3015
a substrate including:\n\nat least one capillary formed therein, the capillary having a first end with a microablation heater associated therewith, the microablation heater including a conductive serpentine pathway connected to electrodes for generating current therein, wherein the microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject's skin in order to access interstitial fluid from the epidermis; and\n
a detection system formed on the substrate and located at a second end of the at least one capillary for receiving the accessed interstitial fluid from the at least one capillary and analyzing the interstitial fluid to detect one or more analytes of interest;\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 1 wherein the substrate is approximately 300 μm thick."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 1 wherein the analytes of interest are selected from the group consisting of glucose, bilirubin, D-amino acids, an insecticide, atropine, pralidoxime, cytokine, dextromethorphan, caffeine, antihistamines, an organophosphate, microbial toxin, inflammatory sequeli to microbial toxin, spore metabolite, prealbumin, C-reactive protein, troponin I, estrogen, and testosterone."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 1, wherein the confined volume of the stratum corneum is 50 μm×50 μm×30 μm."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 1, wherein the microablation heater protrudes from a surface of the substrate."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 5, wherein the microablation heater is formed on a mesa that protrudes from the substrate."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 1, wherein the microablation heater includes a heat-sink material."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["A transdermal sampling system, comprising:\nwherein a length of the at least one capillary is perpendicular to a skin contact surface of the substrate.\n
a substrate including:\n"],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 8 wherein the substrate is approximately 300 μm thick."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 8 wherein the analytes of interest are selected from the group consisting of glucose, bilirubin, D-amino acids, an insecticide, atropine, pralidoxime, cytokine, dextromethorphan, caffeine, antihistamines, an organophosphate, microbial toxin, inflammatory sequeli to microbial toxin, spore metabolite, prealbumin, C-reactive protein, troponin I, estrogen, and testosterone."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 8, wherein the each individual confined volume of the stratum corneum is 50 μm×50 μm×30 μm."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 8, wherein each microablation heater protrudes from a surface of the substrate."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 12, wherein the microablation heater is formed on a mesa that protrudes from the substrate."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 8, wherein each microablation heater includes a heat-sink material."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 8, wherein each microablation heater includes a conductive serpentine pathway connected to the electrodes."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["A transdermal sampling system, comprising:\nmultiple capillaries formed therein, each of the multiple capillaries having a first end associated with a microablation heater, each microablation heater including electrodes for generating current therein, wherein each microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject's skin at separate times in order to access interstitial fluid from the epidermis; and\na detection system formed on the substrate at a second end of each of the multiple capillaries for receiving the accessed interstitial fluid from each of the multiple capillaries at separate times and analyzing the interstitial fluid from each of the independent confined volumes of the stratum corneum to detect one or more analytes of interest,\nwherein a length of each of the multiple capillaries is perpendicular to a skin contact surface of the substrate.\n
a first substrate including:\n\nan array of capillaries formed therein, each capillary includes a first end and second end thereof;\nan individual microablation heater associated with a first end of each capillary, each microablation heater including electrodes for generating current therein, wherein each microablation heater is configured to ablate an individual confined volume of the stratum corneum of a subject's skin in order to access interstitial fluid from the epidermis; and\na detection system formed on the substrate at a second end of each capillary for receiving the accessed interstitial fluid from each capillary at separate times and analyzing separately the interstitial fluid from each of the independent confined volumes of the stratum corneum received from a corresponding capillary in the array to detect one or more analytes of interest;\nwherein a length of each of the capillaries is perpendicular to a skin contact surface of the substrate;\n
a second substrate including at least a logic module and associated circuitry, wherein the logic module and associated circuitry is configured to control each of the microablation heaters and the detection system; and\n
further wherein the first substrate is removably connected to the second substrate and is replaceable with a third identical substrate."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16 wherein the first substrate is approximately 300 μm thick."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16 wherein the analytes of interest are selected from the group consisting of glucose, bilirubin, D-amino acids, an insecticide, atropine, pralidoxime, cytokine, dextromethorphan, caffeine, antihistamines, an organophosphate, microbial toxin, inflammatory sequeli to microbial toxin, spore metabolite, prealbumin, C-reactive protein, troponin I, estrogen, and testosterone."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16, wherein the each individual confined volume of the stratum corneum is 50 μm×50 μm×30 μm."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16, wherein each microablation heater protrudes from a surface of the substrate."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 20, wherein the microablation heater is formed on a mesa that protrudes from the substrate."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16, wherein microablation heater includes a heat-sink material."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16, wherein microablation heater further includes a conductive serpentine pathway connected to the electrodes."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16, wherein analyzing separately the interstitial fluid from each of the independent confined volumes occurs at separate times."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The system of claim 16, wherein analyzing separately the interstitial fluid from each of the independent confined volumes occurs simultaneously."],"number":25,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}