A Method For Detecting The Binding Between Mdm2 And The Proteasome


This invention provides both nucleic acid and amino acid sequences encoding for isolated protein-HDM2 binding sites as well as for isolated protein-proteasome binding sites (the ED(X)Y sequences). In a further aspect this invention also provides related nucleic acids, amino acids, vectors, host cells, pharmaceutical compositions and articles of manufacture. This invention further provides methods for determining whether a test compound interacts with the binding between HDM2 and the proteasome, as well as pharmaceutical compositions comprising said test compound, in particular as anti-cancer agent, even more particular for treating cell proliferative disorders in a subject.

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Document History
  • Publication: Nov 6, 2008
  • Application: Apr 25, 2008
    WO EP 2008055088 W
  • Priority: Apr 26, 2007
    EP EP 07107042 A

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