Regulation Of The Ras/camp/pka Signaling Pathway In Yeasts


The present disclosure relates to the modulation in the RAS/cAMP/PKA signaling pathway for maintaining the propagation efficiency and increasing fermentation efficiency of yeast cells. The present disclosure provides yeast cells having or engineered to exhibit a modulation in signaling in a RAS/cAMP/PKA pathway, depending on conditions. For example the yeast cells can be selected or genetically modified to express a mutated Ras1 protein, a mutated Ras2 protein, a mutated Ira1 protein and/or a mutated Ira2 protein, optionally in combination with specific promoters. Also provided herewith are methods for propagating the yeast cells as well as using the yeast cells to generate a fermented product (such as ethanol).

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Document History
  • Publication: Sep 21, 2017
  • Application: Mar 17, 2017
    WO EP 2017056456 W
  • Priority: Mar 18, 2016
    US US 201662310251 P

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