Inhibition Of Dna Methyltransferase


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The present invention relates to the interplay between the level of DNA methyltransferase and demethylase activities, to the role of the interplay between these levels on the proliferative, differentiated, tumorigenic and homeostatic state of the cell, and to the DNA methyltransferase and demethylase as therapeutic targets. The invention further relates to a reduction of the level of DNA methylation through inhibitors and antagonist in order to inhibit the excessive activity or hypermethylation of DNA MeTase in cancer cells to induce the original cellular tumor suppressing program, to turn on alternative gene expression programs, to provide therapeutics directed at a nodal point of regulation of genetic information, and to modulate the general level of methylase and demethylase enzymatic activity of a cell to permit specific changes in the methylation pattern of a cell.


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Document History
  • Publication: Feb 6, 2001
  • Application: May 30, 1996
    US US 65242596 A
  • Priority: Nov 30, 1994
    CA CA 9400659 W
  • Priority: Jul 7, 1994
    GB GB 9413680 A
  • Priority: Nov 30, 1993
    CA CA 2110213 A

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