Systems, Methods, And Workflows For Optogenetics Analysis


The invention provides methods for characterizing cellular physiology by incorporating into an electrically excitable cell an optical reporter of, and an optical actuator of, electrical activity. A signal is obtained from the optical reporter in response to a stimulation of the cell. Either or both of the optical reporter and actuator may be based on genetically-encoded rhodopsins incorporated into the cell. The invention provides all optical methods that may be used instead of, or as a complement to, traditional patch clamp technologies and that can provide rapid, accurate, and flexible assays of cellular physiology.

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Document History
  • Publication: Dec 8, 2015
  • Application: Jun 12, 2014
    US US 201414303178 A
  • Priority: Jun 12, 2014
    US US 201414303178 A
  • Priority: May 13, 2013
    US US 201313818432 A
  • Priority: Aug 23, 2011
    US US 2011/0048793 W
  • Priority: Nov 12, 2010
    US US 41297210 P
  • Priority: Aug 23, 2010
    US US 37604910 P

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