{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"129-349-567-774-198","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"129-349-567-774-198"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10791,"type":"PATENT","title":"The Hebrew University of Jerusalem - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":7593,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8259,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"hebrew univ* jerusalem\"; \"hebrew univ* jerus*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1457
Search Applicants and Owners separately: \"hebrew univ* jerusalem\"; \"hebrew univ* jerus*\"
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1457
1) an external storage solution having a first osmolality, comprising:\n\nat least one water soluble, lipid permeable active agent having a first concentration,\n\nwherein the at least one water soluble, lipid permeable active agent has a molecular weight of less than or equal to 500 Da, and a LogP of greater than 2.2,\nwherein the at least one water soluble, lipid permeable active agent has a molecular weight of less than or equal to 500 Da, and a LogP of greater than 2.2 is selected from the group consisting of chloroprocaine, ciprocaine, cocaine, cyclomethycaine, dimethocaine, etidocaine, propoxycaine, proparacaine, tetracaine, bupivacaine, cinchocaine, levobupivacaine, lidocaine, piperocaine, ropivacaine, dibucaine, heptacaine, mesocaine, propanocaine, carbisocaine, butacaine, betamethasone hemisuccinate and methyl prednisolone succinate; and\n
2) particles contained within the external storage solution, wherein the particles comprise:\n"],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the liposomes are at least one of multilamellar vesicles (MLVs) or multivesicular vesicles (MVVs)."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the polymer of the matrix is a fully cross-linked polymer or partially cross-linked polymer."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 3, wherein the polymeric matrix is a hydrogel, the hydrogel comprises at least one cross-linked polysaccharide, the polysaccharide being selected from the group consisting of alginate and chitosan."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the first concentration of the at least one water soluble, lipid permeable active agent having a molecular weight of less than or equal to 500 Da, and a LogP of greater than 2.2 is between 0.2% to 2.0%."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the liposomes are large multivesicular vesicles (LMVV) having a diameter of between 200 nm to 25 μm."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the particles are administered to a subject in need thereof."],"number":7,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}i) a water insoluble, water absorbed cross-linked polymeric matrix;\nii) liposomes contained within the water insoluble, water absorbed cross-linked polymeric matrix,\n\nwherein the liposomes comprise cholesterol and a phosphatidylcholine lipid having a Tm greater than or equal to 41° C.;\nwherein the liposomes have an intraliposomal aqueous compartment, containing an intraliposomal solution having a second osmolality, comprising the at least one water soluble, lipid permeable active agent having a molecular weight of less than or equal to 500 Da, and a LogP of greater than 2.2, at a second concentration;\nwherein the first osmolality is not more than 50 mOsmole higher than the second osmolality;\nwherein the second concentration is at least three times greater than the first concentration; and\nwherein the first concentration increases not more than 2 fold during storage at 4° C. for a period of at least three months.\n