{"search_session":{},"preferences":{"l":"fr","queryLanguage":"fr"},"patentId":"129-180-501-974-145","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"129-180-501-974-145","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8901,"type":"PATENT","title":"University of Michigan Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":14369,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8216,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
Search Applicants and Owners= \"Univ Michigan\", \" Michigan Univ\", \" Univ Michigan NOT state NOT tech NOT Eastern\", \"Univ Michigan NOT technological\", \" Univ Michigan NOT Western\"
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Total patent : 14104
wherein:\n
R1 is selected from the group consisting of dihalophenyl, trihalophenyl, fluoro(trifluoromethyl)phenyl, chloro(trifluoromethyl)phenyl, bromo(trifluoromethyl)phenyl, iodo(trifluoromethyl)phenyl, xylyl, fluorotolyl, chlorotolyl, bromotolyl, iodotolyl, fluoroxylyl, chloroxylyl, bromoxylyl, iodoxylyl, (trifluoromethoxy)phenyl, and cyanophenyl, each of which may be optionally substituted;\n
R2 is -L5-C(═O)R3;\n
R3 is NHNHR9;\n
R9 and R17 are independently selected from the group consisting of H and C1 to C12 alkyl; and\n
L5 is selected from the group consisting of null, C1 to C12 alkylene, and C1 to C12 alkenylene."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound or salt of claim 1 having formula VII:"],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound or salt of claim 1, wherein R1 is selected from the group consisting of:"],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound or salt of claim 1 having a formula selected from the group consisting of C251, C255, C261, C262, C268, C278, C282, C287, C301, C304, C305, C307, C336, C340, and C341:"],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["A composition comprising the compound or salt according to claim 1 and a pharmaceutically acceptable carrier."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["A method of treating a disease or disorder associated with an elevated level of PAI-1 in a subject comprising administering an effective amount of a composition comprising the compound or salt according to claim 1 and a pharmaceutically acceptable carrier to decrease the elevated level of PAI-1 in the subject, wherein the disease or disorder is obesity, insulin resistance, a disease or disorder associated with dysregulation of lipid metabolism, a disease or disorder associated with an elevated level of VLDL or LDL, high cholesterol, fibrosis and fibrotic disease, cerebrovascular disease, fibrinolytic disorder, stroke, coronary heart disease, myocardial infarction, thrombosis, deep vein thrombosis, diabetes, or fibrinolytic impairment."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A method of modulating cholesterol, lipid clearance, and/or lipid uptake in a subject with an elevated level of PAI-1 comprising administering an effective amount of a composition comprising the compound or salt according to claim 1 and a pharmaceutically acceptable carrier in an amount effective to decrease the elevated level of PAI and modulate cholesterol, lipid clearance, and/or lipid uptake in the subject."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the composition increases circulating high density lipoprotein (HDL) and/or decreases circulating very low density lipoprotein (VLDL) in the subject."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the composition inhibits apolipoprotein E (ApoE) or apolipoprotein A (ApoA) binding to VLDL-R."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the composition affects HDL or apolipoprotein E (ApoE) or apolipoprotein A (ApoA) binding to an ApoA receptor."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the composition decreases PAI-1 binding to apolipoprotein E (ApoE), apolipoprotein A (ApoA), and/or VLDL."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the composition binds to PAI-1 in the presence of vitronectin and/or urokinase type plasminogen activator (uPA)."],"number":12,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}