Combinatorial Interleukin-2 Muteins

  • Published: Dec 13, 2007
  • Earliest Priority: Mar 05 2004
  • Family: 33
  • Cited Works: 5
  • Cited by: 0
  • Cites: 1
  • Additional Info: Cited Works Full text

Novel human interleukin-2 (IL-2) muteins or variants thereof, and nucleic acid molecules and variants thereof are provided. Methods for producing these muteins as well as methods for stimulating the immune system of an animal are also disclosed. In addition, the invention provides recombinant expression vectors comprising the nucleic acid molecules of this invention and host cells into which expression vectors have been introduced. Pharmaceutical compositions are included comprising a therapeutically effective amount of a human IL-2 mutein of the invention and a pharmaceutically acceptable carrier. The IL-2 muteins have lower toxicity than native IL-2 or Proleukin ® IL-2, while maintaining or enhancing NK cell-mediated effects, and can be used in pharmaceutical compositions for use in treatment of cancer, and in stimulating the immune response.


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Document History
  • Publication: Dec 13, 2007
  • Application: Mar 7, 2005
    WO US 2005/0007303 W
  • Priority: Jan 21, 2005
    US US 64609505 P
  • Priority: Jul 7, 2004
    US US 58598004 P
  • Priority: Mar 5, 2004
    US US 55086804 P

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