Gamma-1 And Gamma-3 Anti-human Cd23 Monoclonal Antibodies And Use Thereof As Therapeutics


Monoclonal antibodies which specifically bind human CD23, the low affinity receptor for IgE (FceRII/CD23), and contain either a human gamma-1 or human gamma-3 constant domain, are disclosed. The antibodies are useful for modulating or inhibiting induced IgE expression. Accordingly, they have practical utility in the treatment or prophylaxis of disease conditions wherein inhibition of induced IgE production is therapeutically desirable, including allergic conditions, autoimmune diseases and inflammatory diseases.

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Document History
  • Publication: Apr 13, 2010
  • Application: Aug 17, 2007
    US US 84064907 A
  • Priority: Aug 17, 2007
    US US 84064907 A
  • Priority: Sep 28, 2004
    US US 95114004 A
  • Priority: Feb 5, 1998
    US US 1944198 A
  • Priority: Feb 20, 1997
    US US 80308597 A

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