Cardiotrophin-1 Compositions And Methods For The Treatment Of Tumor

Abstract

The invention concerns composititions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of cardiotrophin-1 gene amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the cardiotrophin-1 polypeptide encoded by the amplified gene is believed to be a useful target for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as a predictor of the prognosis of tumor treatment.


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Document History
  • Publication: Aug 21, 2007
  • Application: Jul 21, 2004
    US US 89554504 A
  • Priority: Jul 21, 2004
    US US 89554504 A
  • Priority: Nov 28, 2000
    US US 72370300 A
  • Priority: Aug 25, 2000
    US US 64818300 A
  • Priority: Jan 21, 1999
    US US 23473099 A
  • Priority: Dec 22, 1998
    US US 11329698 P
  • Priority: Mar 2, 1998
    US US 3311498 A
  • Priority: Oct 18, 1996
    US US 73385096 A
  • Priority: May 17, 1995
    US US 44312995 A
  • Priority: Aug 5, 1994
    US US 28630494 A
  • Priority: Apr 25, 1994
    US US 23360994 A

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