Methods And Compositions For Gene Inactivation


Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

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Document History
  • Publication: Dec 6, 2007
  • Application: May 23, 2007
    WO US 2007/0012588 W
  • Priority: Apr 30, 2007
    US US 92691107 P
  • Priority: Sep 26, 2006
    US US 84726906 P
  • Priority: May 25, 2006
    US US 80850106 P

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