Animal Model And Cell-line Expressing Modified Chlorine Channel


The present invention relates to a test system for the identification and testing of active compounds which act on synapic transmission (active compounds for treatment of neuronal diseases), which influence endo/exocytosis, which influence processing of proteins and in particular of active compounds which can be used for treatment of osteoporosis or Paget's disease, for treatment of neurological and neuromuscular diseases and other nerve diseases or as psychotropic pharmaceuticals. The invention furthermore relates to a genetically modified non-human mammal, in which one or more chloride channels from the group consisting of C1C-3, C1C-4, C1C-6 and C1C-7 are not expressed or are expressed non-functionally, and somatic cell lines which are derived from such an animal, and the use thereof for the identification and testing of substances which are suitable for inhibiting chloride channels, in particular C1C-3, C1C-4, C1C-5, C1C-6 and/or C1C-7.

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Document History
  • Publication: May 19, 2009
  • Application: Jul 18, 2003
    US US 62237703 A
  • Priority: Jan 17, 2002
    DK DK 0200038 W
  • Priority: Jan 23, 2001
    DE DE 10102977 A

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