Modulation Of Activity Of Proneurotrophins


The present invention provides agents for inhibiting binding of a pro-neurotrophin to a Vps1 Op-domain receptor, in particular the binding of a pro-NGF or a pro-BDNF to a Sortilin receptor. The invention thus provides agents for the manufacture of a medicament, for treating and/or preventing disease or disorders such as but not limited to neurological, neuropsychiatric and ocular diseases, disorders, and degeneration as well as obesity, diabetes, pain and/or nociception in an individual.

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Document History
  • Publication: Jun 10, 2014
  • Application: Dec 21, 2007
    US US 44842207 A
  • Priority: Dec 21, 2007
    US US 44842207 A
  • Priority: Dec 21, 2007
    DK DK 2007000567 W
  • Priority: Jan 16, 2007
    US US 88077107 P
  • Priority: Dec 21, 2006
    DK DK PA200601692 A

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