{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"123-434-691-998-445","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"123-434-691-998-445"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8877,"type":"PATENT","title":"New York Univ Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15466,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8211,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners seperately = \"New York Univ\", \"New York University NOT \"state\" NOT \"city\" \", \"Univ New York\", \"NYU\".
Search Applicants and Owners separately: stony brook Uni*; stony brook university. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 13
Search Applicants and Owners seperately = \"New York Univ\", \"New York University NOT \"state\" NOT \"city\" \", \"Univ New York\", \"NYU\".
Search Applicants and Owners separately: stony brook Uni*; stony brook university. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 13
A. Preparing a recombinant poliovirus from a poliovirus consisting of a 5′NTR region containing an minimal ribosomal entry site (IRES), and the coding sequences for structural proteins (P1), and for the non-structural proteins (P2 and 3) and a 3′NTR, said poliovirus is selected from the group consisting of wild type serotype 1, serotype 2, and serotype 3, by\n\na. substituting at least domain V of the IRES of the poliovirus with at least domain V of the IRES of Human Rhinovirus serotype 2, also having a 5′NTR region containing an internal ribosomal entry site (IRES), the coding sequences for structural protein (P1), and for the non-structural proteins (P2 and P3) and a 3′NTR,\nb. optionally, substituting P1 of the poliovirus with P1 of a Poliovirus (Sabin), selected from the group consisting of PV1(S), PV2(S) and PV3(S); c. optionally, substituting least 3Dpol of P3 of the poliovirus with at least 3Dpol of P3 of a Poliovirus (Sabin), selected from the group consisting of PV1(S), PV2(S) an PV3(S);\nd. optionally, substituting 3′NTR of the poliovirus with 3′NTR of a Poliovirus (Sabin), selected from the group consisting of PV1(S), PV2(S), and PV3(S); and\n
B. Administering intraveneously, intracerebrally, intramuscularly, intraspinally or intrathecally a composition comprising the recombinant poliovirus, wherein the recombinant poliovirus infects and causes cell lysis in the tumor cells."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The therapeutic method of treating malignant tumors according to claim 1 wherein the recombinant virus is PV1 (R2-5) prepared from poliovirus PV1 (M) and the IRES domains II, III, IV and V thereof are substituted with the IRES domains II, III, IV and V of the Human Rhinovirus serotype 2."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The therapeutic method of treating malignant tumors according to claim 1 wherein the recombinant virus is PV1(R5-6) prepared from poliovirus PVl(M) and the IRES domains V and VI thereof are substituted with the IRES domains V and VI of the Human Rhinovirus serotype 2."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["A therapeutic method of treating malignant tumors comprising:\n
A. Preparing a recombinant poliovirus from a poliovirus consisting of a 5′NTR region containing an minimal ribosomal entry site (IRES), and the coding sequences for structural proteins (P1), and for the non-structural proteins (P2 and 3) and a 3′NTR, said poliovirus selected from the group consisting of wild type serotype 1, serotype 2, and serotype 3, by\n\na. substituting at least a fragment of the nucleotides comprising nt#484–nt#508 of the domain V of the IRES of the poliovirus with the corresponding fragment of nucleotides comprising nt#484–nt#508 of the domain V of the IRES of the Human Rhinovirus serotype 2, also having a 5′NTR region containing an internal ribosomal entry site (IRES), the coding sequences for structural protein (P1), and for the non-structural proteins (P2 and P3) and a 3′NTR,\nb. optionally, substituting P1 of the poliovirus with P1 of a Poliovirus (Sabin), selected from the group consisting of PV1(S), PV2(S) and PV3(S);\nc. optionally, substituting least 3Dpol of P3 of the poliovirus with at least 3Dpol of p3 of a Poliovirus (Sabin), selected from the group consisting of PV1(S), PV2(S) an PV3(S);\nd. optionally, substituting 3′NTR of the poliovirus with 3′NTR of a Poliovirus (Sabin), selected from the group consisting of PVl(S), PV2(S), and PV3(S); and\n
B. Administering intraveneously, intracerebrally, intramuscularly, intraspinally or intrathecally a composition comprising the recombinant poliovirus, wherein the recombinant poliovirus infects and causes cell lysis in the tumor cells."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The therapeutic method of treating malignant tumors according to any one of claim 1 or 4 wherein the malignant tumor is selected from a group consisting of glioblastoma multiforme, medulloblastoma, mammary carcinoma, prostate carcinoma, colorectal carcinoma, hepatocellular carcinoma, bronchial carcinoma, and epidermoid carcinoma."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The therapeutic method of treating malignant tumors according to claim 5 wherein the malignant tumor is glioblastoma multiforme."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The therapeutic method of treating malignant tumors according to claim 4, wherein the recombinant virus is PV1(prr) prepared from PV1(M) and in which a fragment of nucleotides consisting of nucleotide position 484 to nucleotide position 508 of the IRES domain V and nucleotide position 594 to nucleotide position 612 of the IRES domain VI is substituted with corresponding fragment of nucleotides comprising nucleotide position 484 to nucleotide position 508 of the IRES domain V and nucleotide position 594 to nucleotide position 612 of the IRES domain VI, respectively, of the Human Rhinovirus serotype 2."],"number":7,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}