{"search_session":{},"preferences":{"l":"fr","queryLanguage":"fr"},"patentId":"123-391-885-889-514","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"123-391-885-889-514","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":12118,"type":"PATENT","title":"Oklahoma State University Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":1365,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8623,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately:Oklahoma State Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1365
Search Applicants and Owners separately:Univ* Oklahoma. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1968
Search Applicants and Owners separately:Oklahoma State Univ*. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1365
Search Applicants and Owners separately:Univ* Oklahoma. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1968
(a) measuring the level of a plurality of cytokines within a sample previously obtained from a patient;
(b) comparing the cytokine levels with reference levels of the cytokines found in a normal population, and/or in a systemic lupus erythematosus patient population; and
(c) determining if a patient has systemic lupus erythematosus based on the comparison in step (b),wherein the plurality of cytokines includes IL-10, IL-2, IL-4, IL-6, IFN-γ, CCL2/MCP-1, CCL4/MIP-1β, CXCLB/IL-8, VEGF, EGF, and IL-17."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the step of determining further comprises the step of classifying the patient as having mild, intermediate or systemic lupus erythematosus."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the patient sample comprises peripheral blood, serum or plasma."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["A method for assessing treatment for systemic lupus erythematosus, the method comprising the steps of:
(a) measuring the level of a plurality of cytokines within a sample previously obtained from a patient, wherein the patient is a systemic lupus erythematosus patient that had previously been subjected to a treatment;
(b) comparing the level of the plurality of cytokines with reference levels of the cytokines found in a pretreatment sample from said patient; and
(c) determining if the treatment is efficacious,wherein the plurality of cytokines includes IL-10, IL-2, IL-4, IL-6, IFN-γ, CCL2/MCP-1, CCL4/MIP-1β, CXCLB/IL-8, VEGF, EGF, and IL-17."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, wherein the patient sample comprises peripheral blood, serum or plasma."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 4, the method further comprising the step of comparing the level of the plurality of cytokines with reference levels of the cytokines in a normal population and/or in a systemic lupus erythematosus patient population."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["A method for determining if a patient with systemic lupus erythematosus is predisposed to develop a severe systemic lupus erythematosus, the method comprising the steps of:
(a) measuring the level of a plurality of cytokines within a sample previously obtained from a patient;
(b) comparing the levels of the cytokines with reference levels of the cytokines, wherein the reference levels are the median levels of the cytokines found in a sample of a population of healthy individuals and/or in samples of a population of patients having systemic lupus erythematosus; and
(c) determining if said patient is predisposed to develop severe systemic lupus erythematosus,wherein the plurality of cytokines includes IL-10, IL-2, IL-4, IL-6, IFN-γ, CCL2/MCP-1, CCL4/MIP-1β, CXCL8/IL-8, VEGF, EGF, and IL-17."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 7, wherein the patient sample comprises peripheral blood, serum or plasma."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of any of claims 1, 4, or 7, wherein reference levels comprise information about a median level of the cytokines in the patient sample."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["A kit for providing diagnostic information about systemic lupus erythematosus, the kit comprising nucleic acid or antibody probes for determining the level of two or more of IL-10, IL-2, IL-4, IL-6, IFN-γ, CCL2/MCP-1, CCL4/MIP-1β, CXCL8/IL-8, VEGF, EGF, and IL-17."],"number":10,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}