Methods Of Identifying Agents That Modulate Methylation Of Vegfr1 By Smyd3

Abstract

The present invention relates to methods for determining the methyltransferase activity of a polypeptide and screening for modulators of methyltransferase activity, more particularly for modulators of the methylation of VEGFR1 by SMYD3. The invention further provides methods and pharmaceutical compositions for treating and preventing colorectal cancer, hepatocellular carcinoma, bladder cancer and/or breast cancer using a modulator so identified.


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Document History
  • Publication: Jul 22, 2010
  • Application: Jun 13, 2008
    US US 66437808 A
  • Priority: Jun 13, 2008
    US US 66437808 A
  • Priority: Jun 13, 2008
    JP 2008001516 W
  • Priority: Jun 14, 2007
    US US 94407107 P

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