Contulakin-g, Analogs Thereof And Uses Therefor

Abstract

The present invention is directed to contulakin-G (which is the native glycosylated peptide), a des-glycosylated contulakin-G (termed Thr10-contulakin-G), and derivatives thereof, to a cDNA clone encoding a precursor of this mature peptide and to a precursor peptide. The invention is further directed to the use of this peptide as a therapeutic for anti-seizure, anti-inflammatory, anti-shock, anti-thrombus, hypotensive, analgesia, anti-psychotic, Parkinson's disease, gastrointestinal disorders, depressive states, cognitive dysfunction, anxiety, tardive dyskinesia, drug dependency, panic attack, mania, irritable bowel syndrome, diarrhea, ulcer, GI tumors, Tourette's syndrome, Huntington's chorea, vascular leakage, anti-arteriosclerosis, vascular and vasodilation disorders, as well as neurological, neuropharmalogical and neuropsychopharmacological disorders.


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Document History
  • Publication: Feb 24, 2004
  • Application: Jun 29, 2000
    US US 60624700 A
  • Priority: Jun 29, 2000
    US US 60624700 A
  • Priority: Oct 19, 1999
    US US 42079799 A
  • Priority: Apr 23, 1999
    US US 13066199 P
  • Priority: Apr 9, 1999
    US US 12856199 P
  • Priority: Oct 20, 1998
    US US 10501598 P

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