Method Of Inhibiting Biomaterial-induced Procoagulant Activity Using Complement Inhibitors

  • Published: Jul 10, 2013
  • Earliest Priority: Sep 30 2008
  • Family: 9
  • Cited Works: 4
  • Cited by: 0
  • Cites: 7
  • Additional Info: Cited Works Published

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Methods for reducing or eliminating biomaterial-induced procoagulant activity in blood subjected to extracorporeal treatment that exposes the blood to the biomaterial are disclosed. The methods involve treatment of the blood, or the extracorporeal biomaterial, or both, with a complement inhibitor to inhibit C5a/C5aR-mediated tissue factor formation in the blood.


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Document History
  • Publication: Jul 10, 2013
  • Application: Sep 29, 2009
    EP EP 09818360 A
  • Priority: Sep 29, 2009
    US US 2009/0058745 W
  • Priority: Sep 30, 2008
    US US 10145308 P

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