Follistatin Domain Containing Proteins

Abstract

The present invention relates to the use of proteins comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of proteins comprising at least one follistatin domain, excluding follistatin itself, for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration.


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Document History
  • Publication: Aug 11, 2009
  • Application: Feb 21, 2003
    US US 36973803 A
  • Priority: Feb 21, 2003
    US US 36973803 A
  • Priority: Dec 20, 2002
    US US 43464502 P
  • Priority: Feb 21, 2002
    US US 35784602 P

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