{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"118-753-498-590-525","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"118-753-498-590-525","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":7036,"type":"PATENT","title":"St Vincent’s Institute of Medical Research Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":153,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8706,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants = ' St Vincent's institute of medical research' ' \nSt Vincent's inst of Med res' ' St Vin* inst* Med* Res*' ' Inst* S* Vin*\n AND Med* '
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selecting a subject in need of inhibition of osteoclast formation; and\n
contacting an osteoclast progenitor cell with (a) a polypeptide comprising an amino acid sequence comprising at least 90% sequence identity to the amino acid sequence set forth as SEQ ID NO: 3 or (b) a polypeptide comprising a fragment of SEQ ID NO: 3, wherein the polypeptide and the fragment inhibit differentiation of osteoclast progenitor cells, thereby inhibiting osteoclast formation."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the method comprises contacting the osteoclast progenitor cell with the polypeptide comprising the fragment of SEQ ID NO: 3 and wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO: 7."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the osteoclast progenitor cell is in vitro."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the osteoclast progenitor cell is in vivo."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 5."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 6."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 2, wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 7."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the osteoclast progenitor cell is a bone marrow cell."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the osteoclast progenitor cell is a spleen cell."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the osteoclast progenitor cell is a hematopoietic stem cell."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the polypeptide comprises an amino acid sequence comprising at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 3."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein the polypeptide comprises an amino acid sequence comprising at least 98% sequence identity to the amino acid sequence set forth as SEQ ID NO: 3."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 12, wherein the polypeptide comprises the amino acid sequence as set forth as SEQ ID NO: 3."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 13, wherein the polypeptide consists of the amino acid sequence set forth as SEQ ID NO: 3."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the polypeptide comprises a cysteine rich domain."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, further comprising measuring osteoclast formation."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein the subject has postmenopausal osteoporosis, Paget's disease, lytic bone metastases, multiple myeloma, hyperparathyroidism, rheumatoid arthritis, periodontitis, or hypercalcemia of malignancy."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 17, wherein the subject has postmenopausal osteoporosis."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["A method of inhibiting osteoclast formation comprising:\n
contacting an osteoclast progenitor cell with (a) a polypeptide comprising an amino acid sequence comprising at least 90% sequence identity to the amino acid sequence set forth as SEQ ID NO: 3 or (b) a polypeptide comprising a fragment of SEQ ID NO: 3, wherein the polypeptide and the fragment inhibit differentiation of osteoclast progenitor cells; and\n
measuring osteoclast formation to determine if osteoclast formation has been inhibited."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the polypeptide comprises an amino acid sequence comprising at least 95% sequence identity to the amino acid sequence set forth as SEQ ID NO: 3."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 20, wherein the polypeptide comprises an amino acid sequence comprising at least 98% sequence identity to the amino acid sequence set forth as SEQ ID NO: 3."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 21, wherein the polypeptide comprises the amino acid sequence set forth as SEQ ID NO: 3."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 22, wherein the polypeptide consists of the amino acid sequence set forth as SEQ ID NO: 3."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the osteoclast progenitor cell is a bone marrow cell."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the osteoclast progenitor cell is a spleen cell."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the osteoclast progenitor cell is a hematopoietic stem cell."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the method comprises contacting the osteoclast progenitor cell with the polypeptide comprising the fragment of SEQ ID NO: 3 and wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 5, SEQ ID NO: 6, or SEQ ID NO:7."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the osteoclast progenitor cell is in vitro."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the osteoclast progenitor cell is in vivo."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 5."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 6."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 27, wherein the fragment comprises the amino acid sequence set forth as SEQ ID NO: 7."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein the polypeptide comprises a cysteine rich domain."],"number":33,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}