Dna-pk Inhibitors

Abstract

A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R<SUP>1 </SUP>and R<SUP>2 </SUP>are independently selected from hydrogen, an optionally substituted C<SUB>1-7 </SUB>alkyl group, C<SUB>3-20 </SUB>heterocyclyl group, or C<SUB>5-20 </SUB>aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is -NH-C(-O)- or -O-; Y is an optionally substituted C<SUB>1-5 </SUB>alkylene group; X is selected from SR<SUP>3 </SUP>or NR<SUP>4</SUP>R<SUP>5</SUP>, wherein, R<SUP>3</SUP>, or R<SUP>4 </SUP>and R<SUP>5 </SUP>are independently selected from hydrogen, optionally substituted C<SUB>1-7 </SUB>alkyl, C<SUB>5-20 </SUB>aryl, or C<SUB>3-20 </SUB>heterocyclyl groups, or R<SUP>4 </SUP>and R<SUP>5 </SUP>may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is -O-, X is additionally selected from -C(-O)-NR<SUP>6</SUP>R<SUP>7</SUP>, wherein R<SUP>6 </SUP>and R<SUP>7 </SUP>are independently selected from hydrogen, optionally substituted C<SUB>1-7 </SUB>alkyl, C<SUB>5-20 </SUB>aryl, or C<SUB>3-20 </SUB>heterocyclyl groups, or R<SUP>6 </SUP>and R<SUP>7 </SUP>may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and if Q is -NH-C(-O)-, -Y-X may additionally be selected from C<SUB>1-7 </SUB>alkyl.


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Document History
  • Publication: Jul 22, 2008
  • Application: Sep 20, 2005
    US US 23104105 A
  • Priority: Sep 20, 2005
    US US 23104105 A
  • Priority: Sep 20, 2004
    US US 61151504 P

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