Methods Of Predicting Predisposition To Or Risk Of Kidney Disease

Abstract

Methods are disclosed herein for detecting a genetic predisposition to focal segmental glomerulosclerosis (FSGS) or hypertensive end-stage kidney disease (ESKD) or both in a human subject, e.g., by detecting the presence of at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. In a further embodiment, methods are disclosed for detecting resistance of a subject to a disease associated with Trypanosoma infection, e.g., by detecting at least one single nucleotide polymorphism (SNP) in an APOL1 gene, such as the C-terminal exon of an APOL1 gene. Also disclosed are methods for treating a subject infected with T. brucei. The methods include administering a therapeutically effective amount of an APOL1 protein including a S342G substitution, an I384M substitution, and/or a deletion of N388 and Y389 to the subject.


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Document History
  • Publication: Nov 28, 2017
  • Application: Apr 18, 2011
    US US 201113642054 A
  • Priority: Apr 18, 2011
    US US 201113642054 A
  • Priority: Apr 18, 2011
    US US 2011/0032924 W
  • Priority: Apr 18, 2010
    US US 32534310 P

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