{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"116-806-848-277-349","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"116-806-848-277-349"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8903,"type":"PATENT","title":"Johns Hopkins Univ Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":17938,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8218,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Johns Hopkins Univ\", \"Univ Johns Hopkins\"
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Total patents: 12941
Search applicants and owners= \"Johns Hopkins Univ\", \"Univ Johns Hopkins\"
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Total patents: 12941
at least 80% of a polysaccharide with at least one monomer having at least one substituted hydroxyl group, wherein the substituted hydroxyl group has the formula (III), and wherein the degree of substitution of formula (III) on the polysaccharide is less than about 0.2; and\n
polyethylene glycol diacrylate,\nwherein\n
formula (III) is\n\n\n\n—O1—C(O)NR7—CH2CH═CH2 \n\n
and O1 is the oxygen atom of said substituted hydroxyl group and R7 is hydrogen or C1-C4 alkyl,\n
wherein the polysaccharide is dextran, and\n
wherein the polysaccharide is crosslinked by reaction with the polv(ethvlene glycol) diacrylate."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein R7 is hydrogen."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the polysaccharide further comprises a second substituted hydroxyl group having the formula (IV), where formula (III) and formula (IV) are different, and the substituted hydroxyl group of formula (III) and formula (IV) may be on the same or different monomers; wherein formula (IV) is\n
\n\nY—(CR2R3)n—Z\n\n
where Y is −O1- or —O1C(O)—, or —O1C(O)NR1—, O1 is the oxygen atom of said substituted hydroxyl group, and R1 is hydrogen or C1-C4 alkyl; n=1, 2, 3, or 4; Z is selected from the group consisting of —CO2H or NR4R5, where R4 and R5 are independently hydrogen or C1-C4 alkyl;\n
R2 and R3 are independently hydrogen, C1-C4 alkyl, or may combine to form a 3-6 membered ring, and when n>1, R2 and R3 on adjacent carbons may form a double or triple bond, or R2 and R3 on different carbon atoms may form a 3-6 membered ring."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the dextran has an average molecular weight of at least 20,000."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, wherein the poly(ethylene glycol) diacrylate has a molecular weight of at least 2000."],"number":5,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 1, further comprising a protein, oligonucleotide or pharmaceutical agent."],"number":6,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 6, comprising a protein, wherein the protein is a growth factor."],"number":7,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 7, wherein the growth factor is vascular endothelial growth factor (VEGF)."],"number":8,"annotation":false,"title":false,"claim":true},{"lines":["A method of delivering a protein, oligonucleotide or pharmaceutical agent to a subject in need of treatment with the protein, oligonucleotide or pharmaceutical agent, comprising administering to the subject a composition of claim 6."],"number":9,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 9, wherein the composition is administered subcutaneously, or applied topically."],"number":10,"annotation":false,"title":false,"claim":true},{"lines":["A method of increasing vascular regeneration comprising administering to a subject in need thereof a composition according to claim 6 comprising a protein that stimulates vascular regeneration."],"number":11,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 11, wherein the protein is vascular endothelial growth factor (VEGF)."],"number":12,"annotation":false,"title":false,"claim":true},{"lines":["A crosslinked composition comprising\n
a polysaccharide with at least one monomer having at least one substituted hydroxyl group,\n
wherein the polysaccharide is crosslinked by reaction with poly(ethylene glycol) diacrylate; and\n
wherein the polysaccharide includes a first substituted hydroxyl group of formula (I) and a second substituted hydroxyl group of formula (II), wherein formula (I) and formula (II) are different, the degree of substitution of formula (I) on the polysaccharide is less than about 0.2; and the first and second substituted hydroxyl groups may be on the same or different monomer;\n
wherein\n\nformula (I) is\n\n\n\n—O1—X\n\n
where O1 is the oxygen atom of said substituted hydroxyl group, and X is a crosslinkable moiety having a double bond; and\n
formula (II) is\n\n\n\nY—(CR2R3)n—CO2H\n\n
Y is −O1- or —O1C(O)—, or —O1C(O)NR1— where O1 is the oxygen atom of said substituted hydroxyl group, and R1 is hydrogen or C1-C4 alkyl, n=1, 2, 3, or 4, R2 and R3 may be independently hydrogen, C1-C4 alkyl, or may combine to form a 3-6 membered ring, and when n>1, R2 and R3 on different carbon atoms may form a 3-6 membered ring; and the polysaccharide is dextran."],"number":13,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the dextran has an average molecular weight of at least 20,000."],"number":14,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the crosslinkable moiety is derived from glycidyl acrylate, glycidyl methacrylate, methacrylate, acrylate, hydroxyethyl methacrylate, maleic anhydride, or allyl isocyanate."],"number":15,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 15, wherein formula (I) is\n
\n\n—O1—C(O)—NR8—CH2CH═CH2 \n\n
where R8 is hydrogen or C1-C4 alkyl."],"number":16,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the poly(ethylene glycol) diacrylate has a molecular weight of at least 2000."],"number":17,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, wherein the composition is a hydrogel."],"number":18,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 13, further comprising a protein, oligonucleotide or pharmaceutical agent."],"number":19,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 19, comprising a protein, wherein the protein is a growth factor."],"number":20,"annotation":false,"title":false,"claim":true},{"lines":["The composition of claim 20, wherein the growth factor is vascular endothelial growth factor (VEGF)."],"number":21,"annotation":false,"title":false,"claim":true},{"lines":["A method of delivering a protein, oligonucleotide or pharmaceutical agent to a subject in need of treatment with the protein, oligonucleotide or pharmaceutical agent, comprising administering to the subject a composition of claim 19."],"number":22,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 22, wherein the composition comprises a protein."],"number":23,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 23, wherein said protein is a growth factor."],"number":24,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 24, wherein the protein is vascular endothelial growth factor (VEGF)."],"number":25,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 22 wherein the composition is administered subcutaneously, or applied topically."],"number":26,"annotation":false,"title":false,"claim":true},{"lines":["A method of increasing vascular regeneration comprising administering to a subject in need thereof a composition according to claim 19 comprising a protein that stimulates vascular regeneration."],"number":27,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27, wherein said protein is a growth factor."],"number":28,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 28, wherein the protein is vascular endothelial growth factor (VEGF)."],"number":29,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 27 wherein the composition is administered subcutaneously, or applied topically."],"number":30,"annotation":false,"title":false,"claim":true},{"lines":["A method for sustained release of a therapeutic protein to a subject in need of treatment comprising administering a hydrogel according to claim 22 to the subject."],"number":31,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}