Beta -hydroxyaspartic Acid Derivatives

Abstract

The present invention provides blockers for glutamate transporters. During a series of syntheses searching for glutamate uptake inhibition in Xenopus oocytes injected with bovine glutamate transporter genes (BGLAST), we obtained beta -hydroxyaspartic acid derivatives of the following chemical formula (1): wherein R represents an aromatic acyl group which may be substituted on the ring, a straight or branched lower aliphatic acyl group, an aryl group which may be substituted on the ring, an aralkyl group which may be substituted on the ring, or a straight or branched lower alkyl group; and salts thereof. These compounds are blockers of glutamate transporters, which are useful for the understanding of the function of glutamate transporters and show promise for the treatment of various neurodegenerative diseases.


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Document History
  • Publication: Nov 14, 2000
  • Application: Oct 24, 1997
    US US 95744097 A
  • Priority: Oct 25, 1996
    JP 31845696 A

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