Dehydrophenylahistins And Analogs Thereof And The Synthesis Of Dehydrophenylahistins And Analogs Thereof


Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R1, R1′, R1′, R2, R3, R4, R5, and R6, X1 and X2, Y, Z, Z1, Z2, Z3, and Z4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating cancer and fungal infection are also disclosed.

Download PDF
Document Preview
Document History
  • Publication: Jun 7, 2011
  • Application: Jun 7, 2006
    US US 44892406 A
  • Priority: Jun 7, 2006
    US US 44892406 A
  • Priority: Aug 1, 2003
    US US 63253103 A
  • Priority: Feb 24, 2003
    US US 45006303 P
  • Priority: Sep 16, 2002
    US US 41112802 P
  • Priority: Aug 2, 2002
    US US 40107402 P

Download Citation

Sign in to the Lens