Carbamic Acid Compounds Comprising A Sulfonamide Linkage As Hdac Inhibitors

Abstract

This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: -S(-O)2NR1- and -NR1S(-O)2-; R1 is a sulfonamido substituent; and, Q2 is an acid leader group; with the proviso that if J is -S(-O)2NR1-, then Q1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.


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Document History
  • Publication: Jul 7, 2009
  • Application: Feb 13, 2008
    US US 3039708 A
  • Priority: Feb 13, 2008
    US US 3039708 A
  • Priority: Sep 7, 2006
    US US 51662006 A
  • Priority: Sep 30, 2004
    US US 95310604 A
  • Priority: Aug 20, 2003
    US US 38179003 A
  • Priority: Sep 27, 2001
    GB GB 0104326 W
  • Priority: Jul 30, 2001
    US US 30813601 P
  • Priority: Jun 14, 2001
    US US 29778401 P
  • Priority: Sep 29, 2000
    GB GB 0023986 A

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