Abstract
The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.
Claims
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An isolated compound of the structural Formula (IIa):
wherein at least one of R1, R2, R3, R4, and R5 substituents is always a sulfur-containing substituent and where R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen, hydroxy, amino, nitro, iodo, bromo, fluoro, (C1-C6) alkyl, (C1-C6) alkoxy, (C3-C7) cycloalkyl, and phenyl, wherein at least two of the five R1, R2, R3, R4, and R5 substituents are always hydrogen, and wherein the sulfur-containing substituent is selected from the group consisting of:
or a pharmaceutically acceptable salt thereof.
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An isolated compound selected from the group consisting of:
or a salt thereof, and
a compound of formula MS213
wherein R6 is selected from the group consisting of alkoxy (C1-C8), isoquinolinones, thiazole, oxazole, oxadiazole, and thiophene, or a salt thereof.
- The isolated compound of claim 2, wherein said compound is in the form of a pharmaceutically acceptable salt thereof.
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An isolated compound of the formula MS 213:
wherein R6 is selected from the group consisting of alkoxy(C1-C8), isoquinolinones, thiazole, oxazole, oxadiazole, and thiophene, or a pharmaceutically acceptable salt thereof.
Owners (US)
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Bipar Sciences Inc
(Nov 12 2007)
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Applicants
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Moore Jerome
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Keyt Bruce
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Burnier John
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Sherman Barry M
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Totrov Max
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Ossovskaya Valeria S
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Bipar Sciences Inc
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Inventors
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Moore Jerome
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Keyt Bruce
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Burnier John
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Sherman Barry M
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Totrov Max
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Ossovskaya Valeria S
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CPC Classifications
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C07C323/62
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C07C233/65
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C07C235/46
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C07C237/30
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C07C239/18
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IPC Classifications
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C07C233/65
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C07C323/42
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C07C323/62
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Document Preview
- Publication: Mar 27, 2012
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Application:
Sep 5, 2007
US 85062607 A
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Priority:
Sep 5, 2007
US 85062607 A
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Priority:
Sep 5, 2006
US 84247406 P