US 8143447 B2 - Treatment Of Cancer - The Lens - Free & Open Patent and Scholarly Search

Patents

US 8143447 B2

Treatment Of Cancer

Published: Mar 27, 2012
Earliest Priority: Sep 05 2006
Family: 12
Cited Works: 100
Cited by: 1
Cites: 101
Additional Info: Cited Works Full text Published

Abstract

The present invention provides compositions of matter, kits and methods for their use in the treatment of cancer. In particular, the invention provides compositions and methods for treating cancer in a subject by inhibiting a poly-ADP-ribose polymerase, as well as providing formulations and modes of administering such compositions.

Claims

An isolated compound of the structural Formula (IIa):
wherein at least one of R₁, R₂, R₃, R₄, and R₅substituents is always a sulfur-containing substituent and where R₁, R₂, R₃, R₄, and R₅are independently selected from the group consisting of hydrogen, hydroxy, amino, nitro, iodo, bromo, fluoro, (C₁-C₆) alkyl, (C₁-C₆) alkoxy, (C₃-C₇) cycloalkyl, and phenyl, wherein at least two of the five R₁, R₂, R₃, R₄, and R₅substituents are always hydrogen, and wherein the sulfur-containing substituent is selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.
An isolated compound selected from the group consisting of:
or a salt thereof, and

a compound of formula MS213

wherein R₆is selected from the group consisting of alkoxy (C₁-C₈), isoquinolinones, thiazole, oxazole, oxadiazole, and thiophene, or a salt thereof.
The isolated compound of claim 2, wherein said compound is in the form of a pharmaceutically acceptable salt thereof.
An isolated compound of the formula MS 213:
wherein R₆is selected from the group consisting of alkoxy(C₁-C₈), isoquinolinones, thiazole, oxazole, oxadiazole, and thiophene, or a pharmaceutically acceptable salt thereof.

Owners (US)

Bipar Sciences Inc (Nov 12 2007)
Explore more patents:
- View all patents where Owners (US) BIPAR SCIENCES INC

Applicants

Moore Jerome
Explore more patents:
- View all patents where Applicants MOORE JEROME
Keyt Bruce
Explore more patents:
- View all patents where Applicants KEYT BRUCE
Burnier John
Explore more patents:
- View all patents where Applicants BURNIER JOHN
Sherman Barry M
Explore more patents:
- View all patents where Applicants SHERMAN BARRY M
Totrov Max
Explore more patents:
- View all patents where Applicants TOTROV MAX
Ossovskaya Valeria S
Explore more patents:
- View all patents where Applicants OSSOVSKAYA VALERIA S
Bipar Sciences Inc
Explore more patents:
- View all patents where Applicants BIPAR SCIENCES INC

Inventors

Moore Jerome
Explore more patents:
- View all patents where Inventors MOORE JEROME
Keyt Bruce
Explore more patents:
- View all patents where Inventors KEYT BRUCE
Burnier John
Explore more patents:
- View all patents where Inventors BURNIER JOHN
Sherman Barry M
Explore more patents:
- View all patents where Inventors SHERMAN BARRY M
Totrov Max
Explore more patents:
- View all patents where Inventors TOTROV MAX
Ossovskaya Valeria S
Explore more patents:
- View all patents where Inventors OSSOVSKAYA VALERIA S

CPC Classifications

C07C323/62
Explore more patents:
- View all patents where CPC Classifications C07C323/62
- View in Classification Explorer
C07C233/65
Explore more patents:
- View all patents where CPC Classifications C07C233/65
- View in Classification Explorer
C07C235/46
Explore more patents:
- View all patents where CPC Classifications C07C235/46
- View in Classification Explorer
C07C237/30
Explore more patents:
- View all patents where CPC Classifications C07C237/30
- View in Classification Explorer
C07C239/18
Explore more patents:
- View all patents where CPC Classifications C07C239/18
- View in Classification Explorer

IPC Classifications

C07C233/65
Explore more patents:
- View all patents where IPC Classifications C07C233/65
- View in Classification Explorer
C07C323/42
Explore more patents:
- View all patents where IPC Classifications C07C323/42
- View in Classification Explorer
C07C323/62
Explore more patents:
- View all patents where IPC Classifications C07C323/62
- View in Classification Explorer

US Classifications

564/162
Explore more patents:
- View all patents where US Classifications 564/162
- View in Classification Explorer
562/431
Explore more patents:
- View all patents where US Classifications 562/431
- View in Classification Explorer

Download PDF

Document Preview

Document History

Publication: Mar 27, 2012
US 8143447 B2
Application: Sep 5, 2007
US 85062607 A
Priority: Sep 5, 2007
US 85062607 A
Priority: Sep 5, 2006
US 84247406 P

Download Citation