Heterocyclic Inhibitors Of Erk2 And Uses Thereof


Described herein are compounds that are useful as protein kinase inhibitors having the formula:wherein Z<1 >and Z<2 >are each independently nitrogen or CH and Ring A, TmR<1>, QR<2>, UnR<3>, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.

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Document History
  • Publication: Jun 1, 2004
  • Application: Feb 8, 2002
    US US 7169902 A
  • Priority: Feb 8, 2002
    US US 7169902 A
  • Priority: Oct 12, 2001
    US US 32876801 P
  • Priority: Feb 9, 2001
    US US 26781801 P

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