{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"110-405-576-644-065","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"110-405-576-644-065","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":8904,"type":"PATENT","title":"Univ Washington Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":15386,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8219,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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Search Applicants and Owners separately : \"wash* univ* st* lou*\"; \"univ* wash* lou*\"; \"Washington University St Louis\"; \"Wash* U* St Lo*\", \" Wash* U* in St Lo*\";
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Search applicants and owners= \"Univ Washington', \"Washington Univ\", \"University of Washington\", \" Washington University\", \"Univ Washington NOT state\", \" Univ Washington NOT state NOT George\".
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Search applicants and owners= \"Univ Pennsylvania\", \"Pennsylvania Univ\", \"Univ Penns*\", \"Penn* Univ\", \"University of Pennsylvania\", \"Pennsylvania University\".
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a cell membrane-permeant peptide;
a diagnostic or pharmaceutically active substance; and
a functional linker moiety linking said peptide and said diagnostic or pharmaceutically active substance;
wherein said compound further comprises at least one D-amino acid and said functional linker moiety confers target cell specificity to said compound; and
wherein said functional linker moiety interacts with intracellular components; or a pharmaceutically acceptable salt of said compound."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 , wherein the majority of the amino acids comprising said compound are D-amino acids."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 2 , wherein said cell membrane-permeant peptide is comprised of D-amino acids."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 , wherein said cell membrane-permeant peptide is selected from the group consisting of SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, and a peptide derivable from HIV-1 Tat protein."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 4 , wherein said cell membrane-permeant peptide is a peptide derivable from HIV-1 Tat protein."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5 , wherein said peptide derivable from HIV-1 Tat protein comprises at least about four to about nine amino acids."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5 , wherein said peptide derivable from HIV-1 Tat protein comprises Tat amino acids 48-57, SEQ ID NO: 7."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 , wherein said functional linker moiety is selected from the group consisting of a peptide, a protein, an oligonucleotide, a peptide nucleic acid, an oligosaccharide, and a hydrocarbon chain."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 , wherein said functional linker moiety comprises a sequence selected from the group consisting of a peptide or protein binding motif, a protein kinase consensus sequence, a protein phosphatase consensus sequence, a protease-reactive sequence, an α-, β-, or γ-secretase-reactive sequence, a peptidase-reactive sequence, a transferase-reactive sequence, a hydrolase-reactive sequence, an isomerase-reactive sequence, a ligase-reactive sequence, an HIV protease-reactive sequence, an extracellular metalloprotease-reactive sequence, a lysosomal protease-reactive sequence, a β-lactamase-reactive sequence, an oxidoreductase-reactive sequence, an esterase-reactive sequence, a glycosidase-reactive sequence, and a nuclease-reactive sequence."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 9 , wherein said sequence is a protease-reactive sequence."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 10 , wherein said protease-reactive sequence is a caspase protease-reactive sequence."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 11 , wherein said caspase protease-reactive sequence is cleaved by a caspase protease selected from the group consisting of caspase 1, caspase 2, caspase 3, caspase 4, caspase 5, caspase 6, caspase 7, caspase 8, caspase 9, caspase 10, caspase 1 1, caspase 12, and caspase 13."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 , wherein said diagnostic substance is selected from the group consisting of a radionuclide, a relaxivity metal, a fluorochrome, a dye, and an enzyme substrate."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 13 , wherein said radionuclide or relaxivity metal is coordinated to a chelation ligand linked to said functional linker moiety."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 14 , wherein said chelation ligand is selected from the group consisting of modified peptide chelators, or DTPA, EDTA, and DOTA."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 13 , wherein said radionuclide is a radioactive isotope of a metal selected from the group consisting Tc, Ru, In, Ga, Co, Pt, Fe, Os, Ir, W, Re, Cr, Mo, Mn, Ni, Rh, Pd, Nb, Cu, and Ta."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 13 , wherein said relaxivity metal is a paramagnetic isotope of a metal selected from the group consisting of Mn, Cr, Fe, Gd, Eu, Dy, Ho, Cu, Co, Ni, Sm, Tb, Er, Tm, and Yb."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["A composition, comprising a compound comprising:
a cell membrane-permeant peptide;
a diagnostic or pharmaceutically active substance; and
a functional linker moiety linking said peptide and said diagnostic or pharmaceutically active substance;
wherein said compound further comprises at least one D-amino acid and said functional linker moiety confers target cell specificity to said compound; and
wherein said functional linker moiety interacts with intracellular components."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 18 , further comprising a pharmaceutically acceptable carrier, excipient, or diluent."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 18 , wherein the majority of amino acids comprising said compound are D-amino acids."],"number":20,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 20 , wherein said membrane permeant peptide comprises D-amino acids."],"number":21,"annotation":false,"claim":true,"title":false},{"lines":["A kit, comprising a compound comprising:
a cell membrane-permeant peptide;
a metal chelation ligand; and
a functional linker moiety linking said peptide and said metal chelation ligand;
wherein said compound further comprises at least one D-amino acid and said functional linker moiety confers target cell specificity to said compound;
wherein said functional linker moiety interacts with intracellular components; and
a reducing agent capable of reducing a metal that can be coordinately incorporated into said metal chelation ligand."],"number":22,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 1 , wherein said cell membrane-permeant peptide comprises amino acids selected from the group consisting of proteogenic D-amino acids and non-proteogenic amino acids."],"number":23,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 23 , wherein said amino acids comprise modified D-amino acids having substitutions wherein a first plurality of amino acids is substituted by a second plurality of amino acids having a hydropathic index within about 1 of the first plurality of amino acids."],"number":24,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 23 , wherein said amino acids comprise modified D-amino acids having substitutions wherein a first plurality of amino acids is substituted by a second plurality of amino acids having a hydropathic index within about 0.5 of the first amino acid."],"number":25,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5 , wherein said peptide derived from HIV-1 Tat protein comprises SEQ ID NO: 7."],"number":26,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 9 , wherein said sequence is selected from the group consisting of SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11, SEQ ID NO: 12, SEQ ID NO: 22, SEQ ID NO: 23, xR(R/K)x(S/T)x for Protein Kinase A, x(R/K) 2-3 x(S/T)x for Protein Kinase G, x(R/K 1-3 ,x 0-2 )(S/T)(x 0-2 ,R/K 1-3 )x for Protein Kinase C, xRxx(S/T)x for Calmodulin Kinase 1I, SEQ ID NO: 24, SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, SEQ ID NO: 28, and SEQ ID NO: 29 wherein x is any amino acid."],"number":27,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 13 , wherein said radionuclide is a radioactive isotope of a metal selected from the group consisting of Tc-m99, In-111, Ga-67, Ga-68, Cu-64, Ru-97, Cr-51, Co-57, Re-188, and Re-186."],"number":28,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 18 , wherein said composition comprises from about 1 μCi to about 100 mCi of said compound when said compound is conjugated to a radionuclide."],"number":29,"annotation":false,"claim":true,"title":false},{"lines":["The composition of claim 18 , wherein said composition comprises about from about 1 mCi to about 50 mCi when said compound is conjugated to a radionuclide."],"number":30,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 4 , wherein said membrane-permeant peptide comprises at least one D-amino acid."],"number":31,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 4 , wherein the majority of the amino acids comprising said membrane-permeant peptide are D-amino acids."],"number":32,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 4 , wherein said membrane-permeant peptide is comprised of D-amino acids."],"number":33,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5 , wherein said membrane-permeant peptide comprises at least one D-amino acid."],"number":34,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5 , wherein the majority of the amino acids comprising said membrane-permeant peptide are D-amino acids."],"number":35,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 5 , wherein said membrane-permeant peptide is comprised of D-amino acids."],"number":36,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 6 , wherein said membrane-permeant peptide comprises at least one D-amino acid."],"number":37,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 6 , wherein the majority of the amino acids comprising said membrane-permeant peptide are D-amino acids."],"number":38,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 6 , wherein said membrane-permeant peptide is comprised of D-amino acids."],"number":39,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7 , wherein said membrane-permeant peptide comprises at least one D-amino acid."],"number":40,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7 , wherein the majority of the amino acids comprising said membrane-permeant peptide are D-amino acids."],"number":41,"annotation":false,"claim":true,"title":false},{"lines":["The compound of claim 7 , wherein said membrane-permeant peptide is comprised of D-amino acids."],"number":42,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}