{"search_session":{},"preferences":{"l":"es","queryLanguage":"es"},"patentId":"109-541-522-038-685","frontPageModel":{"patentViewModel":{"ref":{"entityRefType":"PATENT","entityRefId":"109-541-522-038-685"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":10777,"type":"PATENT","title":"Kings College London - Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":2321,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8247,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: \"Lond* King* Colle*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1680
Search Applicants and Owners separately: \"Lond* King* Colle*\";
Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 1680
a) providing a cultured human or mouse embryonic stem cell or the human or mouse neural stem cell,\n
b) contacting the stem cell with an oral epithelial cell,\n
c) incubating the contacted stem cell of step b) with the oral epithelial cell for a time sufficient to produce a tooth progenitor cell,\n
wherein the tooth progenitor cell co-expresses Barx-1 and Dlx-5, and\n
wherein the tooth progenitor cell further expresses a combination of tooth gene expression markers capable of specifically identifying the tooth progenitor cell."],"number":1,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1, wherein the combination of tooth gene expression markers capable of specifically identifying the tooth progenitor cell comprises:\n
a) a first tooth gene expression marker selected from the group consisting of Pax-9, Msx-1 and combinations thereof, and\n
b) a second tooth gene expression marker selected from the group consisting of Lhx-6, Lhx-7 and combinations thereof."],"number":2,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the combination of tooth gene expression markers capable of specifically identifying the tooth progenitor cell comprises:\n
a) Msx-1, Lhx-7 and Pax-9, or\n
b) Lhx-6 and Pax-9."],"number":3,"annotation":false,"title":false,"claim":true},{"lines":["The method of claim 1 wherein the combination of tooth gene expression markers capable of specifically identifying the tooth progenitor cell comprises Msx-1, Lhx-7 and Pax-9."],"number":4,"annotation":false,"title":false,"claim":true},{"lines":["A method for inducing differentiation of a cultured human or mouse embryonic stem cell, or b) a human or mouse neural stem cell, the method comprising the steps of:\n
a) providing a cultured human or mouse embryonic stem cell or a human or mouse neural stem cell,\n
b) contacting the stem cell with an oral epithelial cell,\n
c) incubating the contacted stem cell of step b) with the oral epithelial cell for a time sufficient to induce differentiation of the stem cell,\n
wherein the stem cell differentiation comprises the co-expression of Barx-1 and Dlx-5."],"number":5,"annotation":false,"title":false,"claim":true}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}