Role Of Pld1 In Thrombus Formation And Integrin Alpha Iib Beta 3 Activation

  • Published: Jan 12, 2011
  • Earliest Priority: Jul 10 2009
  • Family: 2
  • Cited Works: 60
  • Cited by: 0
  • Cites: 7
  • Additional Info: Cited Works Published
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Abstract

The present invention relates to an inhibitor of phospholipase D1 (PLD1) or an inhibitor of an activator of PLD1 for use in treating or preventing a disorder related to venous or arterial thrombus formation or as a lead compound for developing a drug for treating or preventing a disorder related to venous or arterial thrombus formation. The present invention also relates to a method of treating and/or preventing a disorder related to venous or arterial thrombus formation comprising administering a pharmaceutically effective amount of an inhibitor of phospholipase D1 (PLD1) or an inhibitor of an activator of PLD1 to a subject in need thereof. The present invention further relates to methods of identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of a disorder related to venous or arterial thrombus formation.


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Document History
  • Publication: Jan 12, 2011
  • Application: Jul 10, 2009
    EP EP 09009063 A
  • Priority: Jul 10, 2009
    EP EP 09009063 A

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