Human Igm Antibodies To Chemokine Receptors

Abstract

Human sera from normal (i.e., non-HIV infected) individuals contain certain IgM autoantibodies reactive to chemokine and other lymphocyte-surface receptors. A subset of these IgM autoantibodies that bind to such receptors, particularly CXCR4 and CCR5 receptors, can inhibit HIV-1 from infecting cells. Progression from an asymptomatic HIV-1 infected state to AIDS is determined in part by the level of IgM autoantibodies that inhibit HIV-1 from infecting cells. The claimed invention described herein is a method of using these isolated antibodies for the inhibition of the progression of virus-mediated diseases.


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Document History
  • Publication: Aug 26, 2003
  • Application: Oct 10, 2000
    US US 68481300 A
  • Priority: Oct 10, 2000
    US US 68481300 A
  • Priority: Nov 15, 1999
    US US 43969099 A
  • Priority: Nov 18, 1998
    US US 10893798 P

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