Lipid

  • Published: Jul 3, 2008
  • Earliest Priority: Dec 22 2006
  • Family: 6
  • Cited Works: 0
  • Cited by: 6
  • Cites: 0
  • Additional Info: Full text Published
Abstract

The present invention provides a lipid of the formula (I) R<SUB>3</SUB>R<SUB>4</SUB>N-[Y]<SUB>q</SUB>-(C<SUB>p</SUB>H<SUB>2p</SUB>)-X-Linker-NR<SUB>1</SUB>R<SUB>2</SUB> (I) wherein R<SUB>3</SUB> and R<SUB>4</SUB> are independently selected from H and hydrocarbyl groups; q is an integer selected from 1 to 10; Y represents a group (C<SUB>n</SUB>H<SUB>2n</SUB>)NR<SUB>5</SUB>, wherein (i) when q is 1, n is 2, or (ii) when q is greater than 1, each Y may be the same or different and each n is an integer independently selected from 1 to 10, with the proviso that for at least one unit Y, n is 2, and (iii) each R<SUB>5</SUB> is independently selected from H and hydrocarbyl groups; p is an integer selected from 1 to 10; X is an optional group selected from -NR<SUB>7</SUB>-, -C(=O)-N R<SUB>8</SUB>-, -NR<SUB>9</SUB>-C(=O)-, -C(=O)-, -O-, and -NR<SUB>10</SUB>-C(=0)0-, wherein each R<SUB>7</SUB>, R<SUB>8</SUB>, R<SUB>9</SUB> and R<SUB>10</SUB> is independently selected from H and hydrocarbyl groups, Linker is an optional group selected from amino acid residues, peptide residues and groups of the formula -(OCH<SUB>2</SUB>CH<SUB>2</SUB>)<SUB>1-10</SUB>, -NR<SUB>6</SUB>-(CvH<SUB>2v</SUB>)-C(=O)-, wherein R<SUB>6</SUB> is H or a hydrocarbyl group and v is an integer selected from 1 to 11, and -C(=0)-(CH<SUB>2</SUB>)<SUB>0-10</SUB>-CH<SUB>2</SUB>-C(=0)-; R<SUB>1</SUB> is selected from acyclic groups having from 4 to 30 carbon atoms; and R<SUB>2 </SUB>is selected from H and acyclic groups having from 4 to 30 carbon atoms. Said lipids can be used in a delivery vehicle (e.g. micelle or liposome) for the delivery of one or more (therapeutic or diagnostic) agents.


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Document History
  • Publication: Jul 3, 2008
  • Application: Dec 21, 2007
    WO GB 2007004967 W
  • Priority: Dec 11, 2007
    GB GB 0724193 A
  • Priority: Aug 22, 2007
    ZA ZA 200707053 A
  • Priority: Dec 22, 2006
    ZA ZA 200607957 A

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