Use Of Bmp Antagonists To Regulate Hepcidin-mediated Iron Metabolism

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Abstract

The present invention provides new systems and strategies for the regulation of iron metabolism in mammals. In particular, methods of using agonists and antagonists of TGF-² superfamily members to modulate the expression or activity of hepcidin, a key regulator of iron metabolism, are described. The inventive methods find applications in the treatment of diseases associated with iron overload, such as juvenile hemochromatosis and adult hemochromatosis, and in the treatment of diseases associated with iron deficiency, such as anemia of chronic disease and EPO resistant anemia in end-stage of renal disease. The present invention also relates to screening tools and methods for the development of novel drugs and therapies for treating iron metabolism disorders.


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Document History
  • Publication: Dec 16, 2015
  • Application: Feb 16, 2006
    EP EP 15173396 A
  • Priority: Feb 16, 2006
    EP EP 10196139 A
  • Priority: Feb 16, 2006
    EP EP 06735151 A
  • Priority: Feb 16, 2005
    US US 65347905 P

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