The Use Of Mice Predisposed To Develop Ulcerative Colitis And Colon Cancer To Develop Metabolic Profiles Associated With Same

Abstract

The instant invention is based, at least in part, on the discovery that mice deficient in T-bet develop a form of ulcerative colitis that is transmissible to genetically intact hosts. Accordingly, these animals are useful in the development of metabolic profiles that will enhance the predisposition of a subject to develop ulcerative colitis and/or colon cancer and are useful in the identification of targets for therapeutic intervention.


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Document History
  • Publication: Apr 2, 2009
  • Application: Sep 24, 2008
    WO US 2008/0077455 W
  • Priority: May 21, 2008
    US US 12837608 P
  • Priority: Feb 20, 2008
    US US 6631908 P
  • Priority: Sep 24, 2007
    US US 99503607 P

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