{"search_session":{},"preferences":{"l":"en","queryLanguage":"en"},"patentId":"105-536-880-698-112","frontPageModel":{"patentViewModel":{"ref":{"entityRefId":"105-536-880-698-112","entityRefType":"PATENT"},"entityMetadata":{"linkedIds":{"empty":true},"tags":[],"collections":[{"id":11843,"type":"PATENT","title":"University of Innsbruck Patent Portfolio","description":"","access":"OPEN_ACCESS","displayAvatar":true,"attested":false,"itemCount":376,"tags":[],"user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"notes":[{"id":8455,"type":"COLLECTION","user":{"id":91044780,"username":"Cambialens","firstName":"","lastName":"","created":"2015-05-04T00:55:26.000Z","displayName":"Cambialens","preferences":"{\"usage\":\"public\",\"beta\":false}","accountType":"PERSONAL","isOauthOnly":false},"text":"
Search Applicants and Owners separately: univ* AND Innsbruck. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 329
Search Applicants and Owners separately: univ* AND Innsbruck. Select more for logical variants. Add to collection. Select all patents in the collection and expand by simple families. Add to collection. Total patents: 329
(a) fibroblast growth factor 23 (FGF23); and\n
(b) adiponectin; and\n
identifying a subject having an elevated expression level of FGF23 and/or adiponectin as compared to the standard control or reference sample as being a subject that is undergoing progression of said diabetic kidney disease, wherein said determination of the expression levels of at least one marker selected from FGF23 and adiponectin comprises a quantitative measurement of said marker or said markers, wherein said quantitative measurement comprises an immunological assay or an immuno-detection assay, further wherein said assay is selected from ELISA, CIA, RIA, IRMA and Western-blot."],"number":1,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said method comprises the determination of the expression level of said adiponectin in biological samples from male human subjects suspected to suffer from diabetic kidney disease."],"number":2,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said subject suspected to suffer from diabetic kidney disease show renal impairment or dysfunction."],"number":3,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said diabetic kidney disease is diabetic nephropathy."],"number":4,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said standard control is or is derived from a biological sample of a healthy control individual or from healthy control individuals of the same species as the subject suspected to suffer from a diabetic kidney disease."],"number":5,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said determination of the expression levels of at least one marker selected from FGF23 and/or adiponectin comprises the detection of the FGF23 protein and/or the adiponectin protein in said biological sample or said biological samples."],"number":6,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said biological sample is a tissue sample, a cell sample or a sample derived from a biological fluid."],"number":7,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said biological fluid is selected from the group consisting of blood, feces, and urine."],"number":8,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 8, wherein said blood is selected from whole blood, blood serum and blood plasma."],"number":9,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein said assay is an ELISA."],"number":10,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, wherein an elevated expression level of FGF23 and/or adiponectin as compared to a standard control or a reference sample is indicative for said diabetic kidney disease or the progression of said diabetic kidney disease."],"number":11,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein an elevated level of at least 100 rU/ml of FGF23 protein is predictive for a fast progression of said diabetic kidney disease."],"number":12,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 11, wherein an elevated level of at least 3 μg/ml of adiponectin protein in human male subjects is predictive for a fast progression of said diabetic kidney disease."],"number":13,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 1, said method further comprising the measurement of further markers or of further physiological parameters."],"number":14,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 14, wherein said measurement of further markers or of further physiological parameters comprises the comprising a determination of the glomerular filtration rate."],"number":15,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 15, wherein the glomerular filtration rate is determined by use of the iohexol clearance technique or the iothalamate clearance technique."],"number":16,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 15, wherein an elevation of the glomerular filtration rate is predictive for the progression of said diabetic kidney disease."],"number":17,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 17, wherein an elevated level of the glomerular filtration rate of at least 10 ml/min/1.73 m2 is predictive for the progression of said diabetic kidney disease."],"number":18,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 14, wherein said measurement of further markers or of further physiological parameters comprises the determination of the expression level and/or protein level of apolipoprotein A-IV (ApoA-IV)."],"number":19,"annotation":false,"claim":true,"title":false},{"lines":["The method of claim 19, wherein an elevated ApoA-IV concentration of at least 3 mg/dl is predictive for the progression of said diabetic kidney disease."],"number":20,"annotation":false,"claim":true,"title":false}]}},"filters":{"npl":[],"notNpl":[],"applicant":[],"notApplicant":[],"inventor":[],"notInventor":[],"owner":[],"notOwner":[],"tags":[],"dates":[],"types":[],"notTypes":[],"j":[],"notJ":[],"fj":[],"notFj":[],"classIpcr":[],"notClassIpcr":[],"classNat":[],"notClassNat":[],"classCpc":[],"notClassCpc":[],"so":[],"notSo":[],"sat":[]},"sequenceFilters":{"s":"SEQIDNO","d":"ASCENDING","p":0,"n":10,"sp":[],"si":[],"len":[],"t":[],"loc":[]}}