Bank Vole Prion Protein As A Broad-spectrum Substrate For Rt-quic-based Detection And Discrimination Of Prion Strains

Abstract

In some embodiments, a method is disclosed for detecting a transmissible spongiform encephalopathy in a subject. In some embodiments, the method includes performing a prion protein amyloid seeding assay on a biological sample from the subject to detect PrPD. In additional embodiments, a method is disclosed for discriminating whether a bovine is affected by classical or atypical L-type or H-type bovine spongiform encephalopathy, an ovine is affected by classical or atypical Nor98 scrapie, or a human is affected by sporadic or variant Creutzfeldt- Jakob disease.


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