Human Signal Transduction Serine/threonine Kinase

Abstract

An isolated and purified human Ste20-like serine/threonine signal transduction kinase is described. A cDNA sequence which encodes the native signal transduction molecule is disclosed as well as the structural coding region and the amino acid residue sequence. Methods are provided which employ the sequences to identify compounds that modulate the biological and/or pharmacological activity of the transduction molecule and hence regulate cell physiology. Biologically-effective antisense molecules, as well as dominant negative mutant versions of the biomolecule are described which are suitable for therapeutic use. The invention is also drawn toward the diagnosis, prevention, and treatment of pathophysiological disorders mediated by the signal transduction molecule.


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Document History
  • Publication: Oct 9, 2001
  • Application: Dec 21, 1999
    US US 46844299 A
  • Priority: Dec 21, 1999
    US US 46844299 A
  • Priority: Jun 25, 1999
    US US 34099399 A
  • Priority: Dec 15, 1998
    US US 21193098 A
  • Priority: Dec 19, 1997
    GB GB 9726851 A

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