Composition And Method For Providing Localized Delivery Of A Therapeutic Agent

Abstract

The present invention is a composition for providing localized delivery of a therapeutic agent to a subject. The instant composition is a hydrophilic matrix-based prodrug system, wherein a protease substrate peptide acts as extracellular protease degradable spacer binding the therapeutic agent to a hydrophilic matrix. Release of the therapeutic agent is achieved by localized activity of extracellular proteases thereby providing minimal toxicity of the therapeutic agent and maximum release with protease activity. Methods for producing the instant composition and providing localized delivery of a therapeutic agent to a subject are also provided.


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Document History
  • Publication: May 17, 2011
  • Application: Nov 16, 2007
    US US 94138907 A
  • Priority: Nov 16, 2007
    US US 94138907 A
  • Priority: May 15, 2006
    US US 2006/0018614 W
  • Priority: May 16, 2005
    US US 68142405 P

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